Deregulation of sphingolipid metabolism in Alzheimer's disease

Inborn errors of sphingolipid metabolism.

I T is my intent to gather together facts pertaming to the lipidoses which might serve to focus on current problems and to call attention to possible therapeutic approaches. The particular lipidoses to be discussed involve the accumulation in tissues of sphingolipids and may be referred to as sphingolipidoses. They may be classified as “inborn errors of sphingolipid metabolism” on the basis tha...

Glucose Role in Treatment of Alzheimers’ Disease

1. Dong H, Csernansky JG (2009) Effects of Stress and Stress Hormones on Amyloidβ Protein and Plaque Deposition. J Alzheimers Dis 18: 459-469. 2. Csernansky JG, Dong H, Fagan AM, Wang L, Xiong C, et al. (2006) Plasma cortisol and progression of dementia in subjects with Alzheimer‐ type dementia. Am J Psychiatry 163: 2164-2169. 3. Swaab DF, Raadsheer FC, Endert E, Hofman MA, Kamphorst W, et al. ...

Macrophage Activation in Sickle Cell Disease: the Role of Sphingolipid Metabolism in the Disease State

Current State of Alzheimers Disease Research Therapeutics

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Drug sensitivity and sphingolipid metabolism in CLL.

Management and outcome of patients with CLL have changed during the past decade due to improvements in molecular diagnostics and the implementation of targeted drug therapy.2,3 This rapid progress was due to the discovery of chromosomal changes, the understanding of the prognostic impact of the mutational status of immunoglobulin heavy chain genes, the discovery of prognostic markers and potent...